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Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1501-8
• Oxidation of methotrexate by high-valent metal-oxo species was first explored.
Keywords: Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms Multi-endpoint
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 112-120 doi: 10.1007/s11705-021-2075-5
Keywords: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 404-415 doi: 10.1007/s11684-021-0834-9
Keywords: Zika virus clinical drugs ZIKV inhibitors antivirals repurposing
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Frontiers of Medicine doi: 10.1007/s11684-023-1037-3
Keywords: COVID-19 antiviral drugs mindeudesivir
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
Bingxue Shang, Zhifei Cao, Quansheng Zhou
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 67-78 doi: 10.1007/s11684-012-0176-8
Keywords: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4, Pages 335-340 doi: 10.15302/J-FASE-2015079
Keywords: b-pinene nopinone synthesis 2-amino-3-cyanopyridine anticancer
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1143-2
Specific second-order rate constants were determined for 5-FU and CAP with ozone. Reaction sites were confirmed by kinetics, Fukui analysis, and products. The olefin moiety was the main ozone reaction site for 5-FU and CAP. Carboxylic acids comprised most of the residual TOC for 5-FU. Ozonation removed the toxicity associated with 5-FU and products but not CAP.
Keywords: Ozone 5-fluorouracil Capecitabine Hydroxyl radicals Chemotherapy agents Toxicity
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5
We developed a method for determining 11 abused drugs in water and METH and EPH were the dominant drugs in water Abuse drugs in Beiyunhe River were mainly from Abused drugs in the water would not impair the
Keywords: Drugs of abuse Occurrence Distribution Urban river Environmental risk
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 815-826 doi: 10.1007/s11684-021-0891-0
Keywords: B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic
Vaibhav Mundra, Ram I. Mahato
Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 387-404 doi: 10.1007/s11705-014-1457-3
Keywords: nanocarrier cellular uptake endosomal release nucleic acid drug
Telomeric impact of conventional chemotherapy
Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 411-417 doi: 10.1007/s11684-013-0293-z
Keywords: telomere antineoplasic drugs conventional chemotherapies
LI Zhengming
Strategic Study of CAE 2000, Volume 2, Issue 7, Pages 92-93
Marie-Germaine Bousser
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 22-34 doi: 10.1007/s11684-012-0178-6
Keywords: stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs
Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 374-379 doi: 10.1007/s11684-015-0411-1
This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of<3000 CNY, and with severe or moderate pain than those employed and unemployed (P=0.02), patients educated below college (P=0.013), with family income of≥3000 CNY (P=0.025), and with mild pain (P<0.001), respectively. Logistic regression analysis showed that the family income of≥3000 CNY (OR: 2.50, 95%CI: 1.65–4.51, P=0.021) and mild pain (OR: 1.27, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients.
Keywords: chronic pain inpatient oral paregoric drugs compliance
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10, Pages 1503-1515 doi: 10.1007/s11705-022-2294-4
Keywords: insoluble drugs polymer inhibition crystallization crystal growth kinetics DFT calculations
Title Author Date Type Operation
Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water
Journal Article
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
Journal Article
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
Journal Article
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Journal Article
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
Bingxue Shang, Zhifei Cao, Quansheng Zhou
Journal Article
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
Journal Article
Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
Journal Article
Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
Journal Article
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
Journal Article
nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs
Vaibhav Mundra, Ram I. Mahato
Journal Article
Telomeric impact of conventional chemotherapy
Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye
Journal Article
A Review of the International Workshop on “Technological Upgradation of Drugs/Pharmaceutical & Agrochemical
LI Zhengming
Journal Article
Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang
Journal Article